All 125 actors in both Brothers & Sisters and ER
125 actors have appeared in both Brothers & Sisters and ER, across 440 episodes. The most-credited is John Aylward, Joe Rawling in Brothers & Sisters and Dr. Donald Anspaugh in ER.
| Actor | In Brothers & Sisters | In ER | Eps | Eps |
|---|---|---|---|---|
| John Aylward | Joe Rawling | Dr. Donald Anspaugh | 3 | 74 |
| Michael Beach | Noah Guare | Al Boulet | 2 | 19 |
| Amy Aquino | Dr. Joan Avadon | Dr. Janet Coburn | 4 | 26 |
| John Terry | Dr. Karl West | Dr. David 'Div' Cvetic | 5 | 8 |
| Emily Rose | Lena Branigan | Dr. Tracy Martin | 10 | 11 |
| Danny Glover | Isaac Marshall | Charlie Pratt Sr. | 6 | 4 |
| Matthew Settle | Jonathan Sellers | Brian Westlake | 5 | 5 |
| Eric Christian Olsen | Kyle DeWitt | Travis Mitchell | 6 | 1 |
| John Pyper-Ferguson | Joe Whedon | Tom Coggins | 4 | 1 |
| Mitch Pileggi | Browne Carter | Terry Waters | 3 | 1 |
| Michael B. Silver | Stu Orenbacher | Dr. Paul Myers | 2 | 12 |
| Michael Gross | Edward LeMonde | John "Jack" Carter | 1 | 6 |
| David Brisbin | Senator Wade Newman | Dr. Alexander Babcock | 1 | 19 |
| John Apicella | Frank | Mr. Etheridge | 4 | 1 |
| Paul Cassell | Gary Morris | Ed Gamble | 6 | 1 |
| Deidrie Henry | Dr. Williams | Nichelle Richardson | 1 | 1 |
| Denzel Whitaker | Carter | Hassan | 3 | 1 |
| J. Grant Albrecht | Joe Corvus | ICU Attending, Ronny Faneca | 2 | 2 |
| Marty Ryan | Mike | Brant | 2 | 2 |
| Michael Adler | Doug Manning | Marty, Rick | 2 | 2 |
| Scott Michael Campbell | Young Dennis York | EMT Reilly Brown | 1 | 7 |
| Garry Marshall | Major Jack Wiener | Harry Feingold | 2 | 1 |
| Kay Panabaker | Young Kitty Walker | Melissa Rue | 2 | 1 |
| Brent Jennings | Officer Dunnigan | Nat | 1 | 3 |
| Cara Buono | Rose | Lisa Salamunovich | 3 | 1 |
| John Prosky | Ron Robinson | Mr. Brooks | 1 | 4 |
| Evan Jones | Dan | Todd | 3 | 1 |
| Jim Gleason | Walter Geary | Little Girl's Father | 2 | 1 |
| Keri Lynn Pratt | Amber Trachtenberg | Audrey Hoffman | 4 | 1 |
| Marin Hinkle | Courtney McCallister | Kathy | 3 | 1 |
| Patrick St. Esprit | Bill Stanton | Mr. Thorpe | 2 | 1 |
| Barbara Eve Harris | Carla Brown | Sakina, Mrs. Kendrick | 1 | 3 |
| Shelley Robertson | Lynda, Journalist | Tanya Phillips | 3 | 1 |
| Cristine Rose | Dean Danielle Whitley | Mrs. Martinez | 2 | 1 |
| Michael Hyatt | Dr. Katherine Cortez | Yvonne Devilliere | 2 | 1 |
| Ned Bellamy | Cutler Weeks | Detective | 1 | 2 |
| Romy Rosemont | The Counselor | Joanne Bairos | 2 | 1 |
| Ryan Michelle Bathé | Noreen | Miss Evelyn | 2 | 1 |
| Tom McGowan | Luther Reeves | Joe Bernero | 1 | 2 |
| Shi Ne Nielson | Spa Worker | Med Student Sheila | 1 | 4 |
| Corey Mendell Parker | Adam | Byron Evers | 1 | 1 |
| Eric Pierpoint | Stanley Hancock | Mr. Dwyer | 1 | 1 |
| Irene Roseen | Anya | Inez | 1 | 1 |
| Karl T. Wright | Alan Simms | Dr. Norris | 1 | 1 |
| Nancy Linari | Older Woman #1 | Elizabeth Puro | 1 | 1 |
| Tom Virtue | Dr. Bob Feldman | Pares | 1 | 1 |
| Angela Sargeant | Gladys | Shannon | 2 | 1 |
| Maura Soden | Dr. Barbara Riley | Miranda | 2 | 1 |
| Parvesh Cheena | Jordan | Dr. Agbo | 2 | 1 |
| Carole Gutierrez | B&B Owner | Landlady | 1 | 1 |
| David Denman | Brent Lewinsky | Jeremy Willis / "Angel" | 1 | 1 |
| David Purdham | Barry Henderson | Dr. Kallis | 1 | 1 |
| Jeanette Miller | Louise | Beverly, Flora | 1 | 2 |
| Joan McMurtrey | Doctor Fields | Birdwatcher | 1 | 1 |
| Justin Henry | Dr. Lewis | Med Student James Sasser | 1 | 2 |
| Kathe Mazur | Ann Waterman | Kate Nelson | 1 | 1 |
| Lawrence Mandley | Sgt. Harrell | Jackson, Maintenance Man | 1 | 2 |
| Pamela Shaddock | Board Member | Reporter Winslow | 2 | 1 |
| Randee Heller | Karin | Mrs. Goldberg | 1 | 1 |
| Robert Maffia | Policeman | Perfusionist | 1 | 2 |
| Terry Walters | Lacy | Mrs. Angevine | 1 | 1 |
| Thomas Kopache | Berkeley Goldschmidt | Dr. Stofsky | 1 | 1 |
| Dee Freeman | Kate Lawson | Dr. Lutz | 1 | 2 |
| Jim Jansen | Governor Clay Adamson | Neonatologist | 2 | 1 |
| Barry Gordon | Rabbi | Baxter | 1 | 1 |
| Crista Flanagan | Stacy Hodges | Pam | 1 | 1 |
| Dana Snyder | Office Worker | Paranoid Man | 1 | 1 |
| Eamonn Roche | Neil Burke | Mr. Lang | 1 | 1 |
| Jeanette Brox | Claire Feller | Stacy Miller | 1 | 1 |
| Michael Kostroff | Realtor | Community Theater Director | 1 | 1 |
| Stacy Highsmith | Woman | Sarah Reid | 1 | 1 |
| Susan Grace | Nurse Andrea Osborn | Gloria | 1 | 1 |
| Carol Kiernan | Cousin Margaret | Desk Clerk, Doris | 1 | 2 |
| Stana Katic | Karen Wells | Blaire Collins | 1 | 2 |
| Emilio Rivera | The Sponsor | Emilio Cardazco | 1 | 1 |
| Greta Sesheta | Store Clerk | Mrs. Bassett | 1 | 1 |
| Jim Cantafio | Officiant | Det. Lundberg | 1 | 1 |
| Julia Vera | Mateo's Abuela | Reina | 1 | 1 |
| Megan Follows | Maggie Stephens | Christy Larkin | 1 | 1 |
| Michael Durrell | Judge Howard Chandler | Bob Gilman | 1 | 1 |
| Phil Abrams | Harold Wallace | Rodney | 1 | 1 |
| Wayne Lopez | Pedro | Benitez | 1 | 1 |
| Steven Anderson | Officiant | Dr. Davitch | 1 | 2 |
| Caroline Lagerfelt | Jane | Andrea | 1 | 1 |
| Christine Avila | Anita Lewis | Corazon | 1 | 1 |
| Dale E. Turner | Judge | Daniel Harrison | 1 | 1 |
| Dustin Cyril Robles | Scruffy Man | Kevin | 1 | 1 |
| Elaine Kagan | Judge Driscoll | Mrs. Shearer | 1 | 1 |
| John Rubinstein | Dr. Marc Wilson | Dr. Kenner | 1 | 1 |
| Khamani Griffin | Alex | Clayton Davis | 1 | 1 |
| Tom Choi | Steward | Zafares | 1 | 1 |
| Bella Shaw | Reporter | Robinson, TV Anchor | 1 | 2 |
| Eileen Barnett | Judge | Dr. Robbins | 1 | 1 |
| Geoffrey Wade | Board Member #3 | Darrell Amos | 1 | 1 |
| Kim Delgado | Businessman | Taxi Driver | 1 | 1 |
| Mario Quinonez, Jr. | Eduardo | Aaron Gonzalez | 1 | 1 |
| Michael Edwin | McCallister Employee #1 | Drunk Man | 1 | 1 |
| Ming Lo | Dr. Katz | Lindsey Jang | 1 | 1 |
| Nicki Micheaux | Michele Yearwood | Mrs. Williams | 1 | 1 |
| Scott Klace | Kent Barnes | Chris Halpern | 1 | 1 |
| Toni Torres | Female Soldier | Lorraine | 1 | 1 |
| Anderson Goncalves | Private John Jimpson | Matthew Jarre | 1 | 1 |
| Judith Moreland | Dr. Kate Allenby | Nurse Terry | 1 | 1 |
| Leila Yavari | Josette | Flavia | 1 | 1 |
| Mary Ann Jarou | Hostess | Dora | 1 | 1 |
| Patrick Pankhurst | Panel Chairman | Dr. York | 1 | 1 |
| Scott Haven | Umpire | P.K. Palmer IV | 1 | 1 |
| Stephon Fuller | Video Editor | Transport Tech Jim | 1 | 1 |
| Helen Eigenberg | Mona | Renee Weber Stewart | 1 | 1 |
| Joe O'Connor | Harvey Childs | Mr. Scott | 1 | 1 |
| Juan Carlos Cantu | Diner's Owner | Mr. Rodriguez | 1 | 1 |
| Michael Dempsey | Ed | Mr. Beckwith | 1 | 1 |
| Roz Witt | Attendant | Saleswoman | 1 | 1 |
| Sulekha Ebelle | Hostess | Asha | 1 | 1 |
| Tyler Neitzel | Young Aaron | Casey Bryson | 1 | 1 |
| Alex Reznik | Dr. Paul Rauch | Man | 1 | 1 |
| Alejandra Flores | Rosa | Mrs. Valdez | 1 | 1 |
| Ann Marie Lee | Trisha | Georgia | 1 | 1 |
| Christopher Allport | Governor Michael Bryant | Mr. Strickland | 1 | 1 |
| Susan Pari | Sparky | Mrs. Assad | 1 | 1 |
| James Ritz | Wallace | Mr. Jablonski | 1 | 1 |
| Jesse D. Goins | Andrew Karas | Mr. Paige | 1 | 1 |
| James Hornbeck | Harry Dodelson | Dr. David Zaccarria | 1 | 1 |
| Michelle Noh | Michelle | Kate | 1 | 1 |
| Kathleen M. Darcy | Loan Officer | Judy | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.