All 55 actors in both Frasier and The Simpsons
55 actors have appeared in both Frasier and The Simpsons, across 1,066 episodes. The most-credited is Joe Mantegna, Derek Mann in Frasier and Fat Tony, Fat Tony's Former Father, Gordus Antonius in The Simpsons.
| Actor | In Frasier | In The Simpsons | Eps | Eps |
|---|---|---|---|---|
| Joe Mantegna | Derek Mann | Fat Tony, Fat Tony's Former Father, Gordus Antonius | 1 | 44 |
| Jane Kaczmarek | Maureen Cutler | Judge Constance Harm | 2 | 10 |
| Marcia Mitzman Gaven | Allison Landis | Maude Flanders, Helen Lovejoy, Ms. Hoover | 1 | 9 |
| Megan Mullally | Beth Armstrong | Sarah Wiggum | 1 | 6 |
| Eric Idle | Chuck | Declan Desmond | 1 | 4 |
| Zooey Deschanel | Jen | Mary Spuckler, Quirk Girl | 1 | 4 |
| Beverly D'Angelo | Audrey | Lurleen Lumpkin | 1 | 3 |
| James Earl Jones | Norman Royster | Narrator, Maggie, Moving Man | 1 | 3 |
| Allison Janney | Phyllis, Susanna | Julia | 2 | 1 |
| Dan Castellaneta | Brad | Gerald Ford, Ugolin | 1 | 2 |
| Griffin Dunne | Bob, Russell | Cockroach Actor | 2 | 1 |
| Jane Lynch | Cynthia | Jeanie, Roz Davis | 1 | 2 |
| John Ratzenberger | Cliff Clavin | Cliff, John Ratzenberger | 1 | 2 |
| Michael Keaton | Blaine Sternin | Hal Julian, Jack | 1 | 2 |
| Patrick Stewart | Alistair Burke | Number One, Regular Hairless Joe | 1 | 2 |
| Patti LuPone | Aunt Zora Crane, Pam | Cheryl Monroe | 2 | 1 |
| Sarah Silverman | Jane | Nikki, Rachel, Sarah Silverman | 1 | 4 |
| Alan Cumming | Ahmrit | Loki | 1 | 1 |
| Andy Garcia | Terrence | Publisher | 1 | 1 |
| Brent Spiner | Albert | Robots | 1 | 1 |
| Brian Cox | Harry Moon | Kostas Becker | 2 | 2 |
| Christine Baranski | Dr. Nora Fairchild | Christine Baranski | 1 | 1 |
| David Duchovny | Tom | Fox Mulder | 1 | 1 |
| Diedrich Bader | Brad | Police Officer | 1 | 1 |
| Jodie Foster | Marlene | Maggie | 1 | 1 |
| John Waters | Roger | John | 1 | 1 |
| Lily Tomlin | Rita | Tammy | 1 | 1 |
| Olympia Dukakis | Caller #3 | Zelda | 1 | 1 |
| Penny Marshall | Celeste | America's Most Armed and Dangerous Phone Caller, Lucille Botzcowski | 1 | 1 |
| Rachel Dratch | Horny Date | Doctor | 1 | 1 |
| Rhea Perlman | Carla Tortelli LeBec | Carla | 1 | 1 |
| Stephen Root | Harbin | Bildorf | 1 | 1 |
| Ted Danson | Sam Malone | Sam Malone | 1 | 1 |
| Victor Garber | Ferguson | Michael de Graaf | 1 | 1 |
| Wren T. Brown | Keith Bishop | Virgil | 1 | 1 |
| John Lithgow | Madman Martinez | Augustus Redfield, John Lithgow | 1 | 2 |
| Larry King | Larry King | Larry King | 1 | 2 |
| Ben Stiller | Barry | Garth Motherloving | 1 | 1 |
| George Wendt | Norm Peterson | Norm | 1 | 1 |
| Gillian Anderson | Jenny | Dana Scully | 1 | 1 |
| Illeana Douglas | Kenny's Wife | New Age Clerk | 1 | 1 |
| Jennifer Tilly | Kim | Jennifer Tilly | 1 | 1 |
| Kevin Bacon | Vic | Hotel Philadelphia Concierge | 1 | 1 |
| Mike Judge | Van | Hank Hill | 1 | 1 |
| Ray Liotta | Bob | Morty Szyslak | 1 | 1 |
| Wolfgang Puck | Tom, Wolfgang Puck | Wolfgang Puck | 2 | 1 |
| Yo-Yo Ma | Tom | Yo-Yo Ma | 1 | 1 |
| Elvis Costello | Ben | Elvis Costello | 1 | 1 |
| Mel Brooks | Tom | Mel Brooks | 1 | 1 |
| Richard E. Grant | Stephen Moon | Julian | 1 | 1 |
| Jay Leno | Don | Jay Leno | 1 | 1 |
| Paul Willson | Paul Krapence | Florist, News Reporter #2 | 1 | 1 |
| Woody Harrelson | Woody Boyd | Wood | 1 | 1 |
| Kieran Culkin | Jimmy | Hub | 1 | 1 |
| Paul F. Tompkins | Steve | Colby Redfield | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.