All 66 actors in both Madam Secretary and Nurse Jackie
66 actors have appeared in both Madam Secretary and Nurse Jackie, across 200 episodes. The most-credited is Tonya Pinkins, Susan Thompson, Susan Thomas in Madam Secretary and Charlane in Nurse Jackie.
| Actor | In Madam Secretary | In Nurse Jackie | Eps | Eps |
|---|---|---|---|---|
| Tonya Pinkins | Susan Thompson, Susan Thomas | Charlane | 10 | 2 |
| Patrick Breen | Andrew Munsey | Martin Vobernick | 7 | 1 |
| John Ellison Conlee | Shane McCord | Guidry | 3 | 1 |
| Nilaja Sun | Juliet Humphrey | Tress | 7 | 1 |
| Gbenga Akinnagbe | Chris Santumari | Kelly Slater | 1 | 8 |
| Anna Deavere Smith | Attorney General Mary Perlowski | Dr. Akalitis | 1 | 10 |
| Jordan Lage | General Kohl | AA Overdose | 7 | 1 |
| B.D. Wong | Brent Rosen | Doctor Wu | 2 | 1 |
| John Cullum | Senator Beau Carpenter | Wally | 5 | 1 |
| Deirdre O'Connell | Audrey Stewart | Helen | 1 | 3 |
| Michael Potts | Fred Reynolds | Mediator | 3 | 2 |
| Joel de la Fuente | President Datu Andrada | Father | 3 | 1 |
| Michael Cumpsty | Max Quinn | Lou Babiak | 1 | 2 |
| Starla Benford | Mary Wilford | School Nurse | 2 | 1 |
| André Blake | Secret Service Agent | Orthopedist | 1 | 1 |
| Jessica Hecht | Julia MacDonald | Mimi | 1 | 1 |
| Vanessa Aspillaga | Maria Ayala | Lydia | 1 | 1 |
| Deidre Goodwin | Jessica Moore | Brooke | 2 | 1 |
| Margaret Colin | Judith Fanning | Trish | 1 | 2 |
| Fajer Al-Kaisi | Hezbollah Soldier #1, Smuggler, Translator | Social Worker | 4 | 1 |
| Chuck Cooper | General Mitch Sarno | Intestine Man | 1 | 1 |
| Dennis Staroselsky | Ivan Kolashkov | Dzubenko Son | 3 | 1 |
| Maddie Corman | Donna Parker | Joe's Wife | 2 | 1 |
| Meredith Holzman | FBI Agent Becca Smalls | Trina | 1 | 1 |
| Purva Bedi | Ms. Alvarez | Tazim | 1 | 1 |
| Tim Guinee | Paul Wellington | Joe | 1 | 1 |
| Ed Moran | CIA Interrogator #1 | High School Buddy #2, Queens Dad #1 | 1 | 2 |
| Rob Yang | President Kenatbek Nogoyev | Rumpled Suit Man | 2 | 1 |
| Angel Desai | Vanessa Chung | Cosmetic Surgeon | 1 | 1 |
| Berto Colón | Officer Freeman | Eric Rios | 1 | 1 |
| Cindy Cheung | Dr. Cary | Susan | 1 | 1 |
| Joe Lanza | Militia Leader | Cop | 1 | 1 |
| Alexis Suarez | Security Guard | Nurse #4 | 2 | 1 |
| Becky Ann Baker | Chancellor Frieda Schulz | Elaine | 1 | 1 |
| Kenneth Tigar | Dr. Stuart Bachman | Tottie's son | 1 | 1 |
| Keren Dukes | Marine | Mom | 1 | 1 |
| Leslie Silva | Ms. Hardwick | Receptionist | 1 | 1 |
| Michael Mulheren | Barry Milken | Eddie's Deposition Lawyer | 1 | 1 |
| Darlesia Cearcy | Shira Richie | Stephanie's Mom | 1 | 1 |
| Simon Feil | Doctor | Heart Attack Man | 1 | 1 |
| Stephen O'Reilly | Roy Schaeffer | Matt | 1 | 1 |
| Tijuana Ricks | Rhonda Gunderson | Lady Cop | 1 | 1 |
| Wayne W. Pretlow | Keith | Father Joe | 1 | 1 |
| Andrew Guilarte | Marine #1 | Libyan Executive Secretary | 1 | 1 |
| Debargo Sanyal | Ranuga | Nervous Nurse | 1 | 1 |
| Marceline Hugot | Evelyn Schultz | Pawnbroker | 1 | 1 |
| Megan Byrne | Jessica Wellington | Ruth | 1 | 1 |
| Nancy Lemenager | Natalie Barker | Arden | 1 | 1 |
| Pun Bandhu | Sud | Dr. Saqr | 1 | 1 |
| Rosalyn Coleman | Rep. May Everton | Whitney Prince | 1 | 1 |
| Ali Reza | Bilal Hassani | Farsi Street Vendor | 1 | 1 |
| Betsy Aidem | Nancy Mitchell | Carolyn | 1 | 1 |
| MaryAnn Hu | Press Member | Mrs. Lee | 1 | 1 |
| Michael Elian | Guy #1 | Patient #1 | 1 | 1 |
| Rajesh Bose | Serious Man | Man | 1 | 1 |
| Susan Pourfar | Lena Kaminska | Susie | 1 | 1 |
| Todd Cerveris | Congressman Chivvers | Patient | 1 | 1 |
| Edelen McWilliams | Amy Ferber | Brenda | 1 | 1 |
| Holly Chou | Reporter # 1 | Teller | 1 | 1 |
| Patricia R. Floyd | Patricia | Woman at Podium | 1 | 1 |
| Reathel Bean | Sheriff Gabriel Weston | Father Frank | 1 | 1 |
| Stacey Yen | Georgia | Tech | 1 | 1 |
| Colby Minifie | Bella Rossi | Blithe | 1 | 1 |
| Tom Day | Navy Captain | Business Man | 1 | 1 |
| Maria-Christina Oliveras | Francine Tan | Latino Woman | 1 | 1 |
| Angela Pietropinto | Dog Walker | Mother | 1 | 1 |
← Madam Secretary × Nurse Jackie
Cast data from TVmaze, licensed CC BY-SA 4.0.