All 80 actors in both Murder, She Wrote and Simon & Simon
80 actors have appeared in both Murder, She Wrote and Simon & Simon, across 420 episodes. The most-credited is John Davis Chandler, Gilbert Stoner, John Detweiler in Murder, She Wrote and Arnie Roberts, Charlie, Harry Brookmueller in Simon & Simon.
| Actor | In Murder, She Wrote | In Simon & Simon | Eps | Eps |
|---|---|---|---|---|
| John Davis Chandler | Gilbert Stoner, John Detweiler | Arnie Roberts, Charlie, Harry Brookmueller | 2 | 3 |
| Robert Casper | Arthur Jasper, Dean Howard Cogden | Perkins, Mr. Smithers | 2 | 3 |
| Lyle Waggoner | Ben Wright, Marty Strindberg, Vic DeMarco | Don Manning | 3 | 1 |
| Rosemary Forsyth | Dr. Andrea Jeffreys Reed, Estelle Freelander | Ellen Lottick, Lisa Bannon | 2 | 2 |
| Warren Berlinger | Coach Pat Patillo, Jim Ingram, Sugarman | Mr. Phillips | 3 | 1 |
| Alan Hale Jr. | Fenton Harris | Bartender at Broken Saddle, Silk McNabb | 1 | 2 |
| Dennis Patrick | Dexter Baxendale, P.I., Dr. Robert Markle | Admiral Danforth | 2 | 1 |
| Doug McClure | Gary Patterson, Sheriff Sam Rankin | Murphy | 2 | 1 |
| Henry Gibson | Harold Banner, Oliver Thissle | Herbert T. Dowd | 2 | 1 |
| John Schuck | Captain Davis, Chief Merton P. Drock | Frank Campbell | 2 | 1 |
| Marie Windsor | Caroline, Kate Gunnerson | Wanda | 2 | 1 |
| Nancy Lee Grahn | Erin Carey, Sheila Saxon | Joan | 2 | 1 |
| Richard Herd | Arnett Cobb, Harvey McKittrick | Kyle Edmunds | 2 | 1 |
| Edd Byrnes | Freddie Major, Kenneth Rundle, Sid Hooper | Barry L. Fastman, Howard Hunk, Steve Yellen | 3 | 2 |
| Stuart Whitman | Ben Miller, C.J. Dobbs, Charles Woodley | Buck Yancy/Rough Rider | 4 | 1 |
| Ken Swofford | Lt. Catalano, Alan Forsythe, Grover Barth | Lloyd Getz | 8 | 1 |
| Clyde Kusatsu | Jack Yamoto | Gerald | 1 | 1 |
| Erin Gray | Andrea Dean | Vicki Whittaker | 1 | 1 |
| Gary Lockwood | Harris Talmadge, Sheriff Deloy Hays, Tom Carpenter | Air Force Col. Christopher J. Ahern | 3 | 1 |
| James Shigeta | John Sukahara | Musashi Sato | 1 | 1 |
| Joan Leslie | Lillian Appletree | Toni Meyers | 1 | 1 |
| Kathleen Lloyd | Paula Roman | Sarah Childs | 1 | 1 |
| Pat Corley | Frank Kelso | Mayor K.K. Drinkman | 1 | 1 |
| Peter Graves | Dr. Edmund Gerard | Wade Christian | 1 | 1 |
| Robert Sterling | Ben Shipley | Arthur Bristol/Michael Wells | 1 | 1 |
| Tom Selleck | Thomas Magnum | Thomas Magnum | 1 | 1 |
| William Bryant | Gadge | Cecilia's Date | 1 | 1 |
| John Hillerman | Edgar Greenstreet, Jonathan Quayle Higgins III | Jonathan Quayle Higgins III | 2 | 1 |
| Mills Watson | Glen Roy Sitwell, Ralph Leary | P.I. Arthur 'Artie' Dunnington | 2 | 1 |
| Ray Walston | Q. L. Frubson | Danny 'The Milwaukee Kid' Chesney, Rockwell Stark | 1 | 2 |
| Alan Fudge | Brian Wade, Councilman Axelrod, Derek St. James | George | 4 | 1 |
| Anne Schedeen | Julia Granger | Bailey Randall | 1 | 1 |
| Arlene Golonka | Gloria Winslow, Sally Conover | Joyce Allreed | 2 | 1 |
| Belinda Montgomery | Pamela Crane | Laura Dennison | 1 | 1 |
| Chuck Hicks | Guard | Angry Man | 1 | 1 |
| Daphne Maxwell Reid | Nan Wynn | Temple Hill | 1 | 1 |
| Darleen Carr | Trish Mercer | Dr. Sawyer | 1 | 1 |
| Dick Butkus | Tank Mason | Joe Blake | 1 | 1 |
| Eddie Albert | Jackson Lane | Judge Elliott Morris Taylor | 1 | 1 |
| Edson Stroll | Dr. Peter Weber | Dr. Willis Courtney | 1 | 1 |
| Jennifer Holmes | Reagan Miller, Sandra Clemons | Julie Arthur | 2 | 1 |
| Jerry Stiller | Lt. Birnbaum | Harold Traxler | 1 | 1 |
| Joe Dorsey | Harry Kingman, Ben Devlin, Bennett J. Devlin | Lt. Kaster | 5 | 1 |
| Julius Harris | Jack Lee Johnson | Jules, Montgomery | 1 | 2 |
| June Allyson | Katie Simmons | Margaret Wells | 1 | 1 |
| Katherine Moffat | Lauren Hastings, Millicent Moore | Diane Pierce | 2 | 1 |
| Lance LeGault | RCMP Inspector Roger McCabe | Col. Paul Stark | 1 | 1 |
| Lonny Chapman | Addison Langley, Frank Hemet, Jack Bowen | Agent Grover | 3 | 1 |
| Morgan Fairchild | Iris Novaro | Catherine Hailey | 1 | 1 |
| Nicholas Pryor | Harry Parmel, Theo Coyle | Victor Farrell | 2 | 1 |
| Nicolas Coster | Dr. Craig Zachary | City Attorney David Stallings, Derek Fry | 1 | 2 |
| Sharon Acker | Wilhelmina Fraser | Helena Christian | 1 | 1 |
| Thom Christopher | Dimitri Popadopalous, Rev. Willard Manchester | Priest | 2 | 1 |
| Thomas Callaway | Sam Bryce | Connell | 1 | 1 |
| Alex Rocco | Bert Yardley, Ernie Santini | Hank Galante | 2 | 1 |
| Alex Henteloff | Raymond Parnell | Herbie Groescher | 1 | 1 |
| Charles Napier | Hank Sutter, Denver Martin | Gibson | 3 | 1 |
| Darrell Zwerling | Doctor | H.M. Hadley | 1 | 1 |
| Gary Crosby | Ted Stully | Stan Tucker | 1 | 1 |
| Gregory Walcott | Isaiah Potts, Lamar Morgan, Willie Patchecki | Kramer | 3 | 1 |
| Kenneth Mars | Hemsley Post | Ben Dodge | 1 | 1 |
| Sandy McPeak | Bill Spenser, Morgan Rogers, Spruce Osborne | FBI Undercover Agent | 3 | 1 |
| Tom Hallick | Preston Wardell, Vice Chancellor Simon | Doug Sullivan | 2 | 1 |
| Christina Hart | Sister Maria | April the flight attendant | 1 | 1 |
| Louise Fitch | Nosy Neighbor | Mrs. Mitchell | 1 | 1 |
| Pepe Hern | Antonio | Leon Mendoza | 1 | 1 |
| Ruta Lee | Renee | Penny Russell | 1 | 1 |
| Sondra Currie | Carol Kendall | Claire Hipple | 1 | 1 |
| Alex Hyde-White | Ogden Schmesser | Poolside Steve | 1 | 1 |
| Bert Rosario | Carlos Gallego | Enriquez | 1 | 1 |
| Don Stroud | Carey Drayson | Arnold | 1 | 1 |
| Edward Bell | Barry McAdams | Thornberry | 1 | 1 |
| Howard Witt | Bart Nelson | Joey Marcotte | 1 | 1 |
| Michael Ansara | Nicholas Rossi | Bill Waller | 1 | 1 |
| Norman Burton | Drew Narramore | Carl Emory | 1 | 1 |
| R.J. Arterburn | Sergeant | Bartender | 1 | 1 |
| Tom Reese | Hitman | Frost | 1 | 1 |
| Whitney Rydbeck | Hastings | Wally Byrnes | 1 | 1 |
| Barbara Lynn Block | TV Newswoman | Anne Blake | 1 | 1 |
| Alice Nunn | Henrietta | Barney | 1 | 1 |
← Murder, She Wrote × Simon & Simon
Cast data from TVmaze, licensed CC BY-SA 4.0.