All 89 actors in both Murder, She Wrote and The Twilight Zone
89 actors have appeared in both Murder, She Wrote and The Twilight Zone, across 420 episodes. The most-credited is William Windom, Dr. Seth Hazlitt, Sam Breen in Murder, She Wrote and Dr. Wallman, The Major in The Twilight Zone.
| Actor | In Murder, She Wrote | In The Twilight Zone | Eps | Eps |
|---|---|---|---|---|
| William Windom | Dr. Seth Hazlitt, Sam Breen | Dr. Wallman, The Major | 48 | 2 |
| Ron Masak | Sheriff Mort Metzger, Lt. Meyer, Marty Giles | Harmonica Man | 38 | 1 |
| Anne Francis | Lee Haley, Louise McCallum, Margo Perry | Jess-Belle Stone, Marsha White | 3 | 2 |
| Claude Akins | Captain Ethan Cragg | Steve Brand | 4 | 1 |
| John Anderson | Andrew Dixon | Capt. 'Skipper' Farver, Deidrich, Gabriel | 1 | 4 |
| Kevin McCarthy | Milton Porter, Randolph Sterling, Walter Bowman | Professor Walter Jameson/Tom Bowen/Major Hugh Skelton | 3 | 1 |
| Lloyd Bochner | Dr. Terence Mayhew, Jason Richards, John Thurston | Michael Chambers | 3 | 1 |
| Lois Nettleton | Amelia, Deidre French, Ginny Blanchard | Norma | 3 | 1 |
| Martin Balsam | Edgar Carmody | Danny Weiss, Martin Lombard Senescu | 2 | 2 |
| Martin Milner | Major Clint Phelps, Sheriff Bodine | Paul Grinstead | 3 | 1 |
| Morgan Jones | Sergeant Baxter, Sergeant Tierney | Captain, Trooper Dan Perry | 2 | 2 |
| Steve Forrest | Lt. Paul Stratton, Reverend Willie John Fargo, Sheriff Hank Masters | Major Robert Gaines | 3 | 1 |
| Jackie Cooper | Carl Schulman / Neil Fletcher | Caesar, Jonathan West | 2 | 1 |
| Joseph Ruskin | Ivanov | Genie, Kanamit | 1 | 2 |
| Martin Landau | Al Drake | Dan Hotaling, Major Ivan Kuchenko | 1 | 2 |
| Orson Bean | Ebeneezer McEnery | James B. W. Bevis | 2 | 1 |
| Pat Hingle | Ret. Det. Barney Kale, Zach Franklin | Horace Ford | 2 | 1 |
| Patrick Macnee | Dayton Whiting, Oliver Trumbull | First Officer McLeod | 2 | 1 |
| Robert Cornthwaite | Mr. Coroner | Director, Hanford | 1 | 2 |
| Roddy McDowall | Dr. Alger Kenyon, Gordon Fairchild | Sam Conrad | 2 | 1 |
| Robert Hogan | Dr. Wylie Graham, FBI Agent Guilfoyle, Lt. Bergkamp | Robert Blake | 4 | 1 |
| Barry Nelson | Eugene McClenden | Bob Frazier | 1 | 1 |
| Bob Hastings | Eddie Bender | Sam | 1 | 1 |
| Dean Stockwell | Elliot Easterbrook | Lt. Katell, Lt. Yamuri | 1 | 1 |
| Denver Pyle | Eben Connors | Stu Tillman | 1 | 1 |
| George Grizzard | Dr. Aubrey Benton, Edmund Hall, Prof. Tyler Stoneham | Roger Shackleforth | 3 | 1 |
| George Takei | Bert Tanaka | Arthur Takamori / Taro | 1 | 1 |
| Greg Morris | Lt. Andrews | Lt. Woodard | 1 | 1 |
| John Astin | Harry Pierce, Fritz Randall, Ross Hayley | Charlie | 5 | 1 |
| Joseph V. Perry | Heavy Set Crude Man, Ralph | Office Worker, Police Lieutenant | 2 | 2 |
| Mickey Rooney | Matt Cleveland | Grady | 1 | 1 |
| Murray Hamilton | Bud Michaels | Mr. Death | 1 | 1 |
| Peter Mark Richman | Lamar Bennett | Trooper Robert Franklin | 1 | 1 |
| Phyllis Thaxter | Emily Weymouth | Virginia Lane Walker | 1 | 1 |
| Robert Sterling | Ben Shipley | Douglas Winter | 1 | 1 |
| Ruta Lee | Renee | Flora Gordon | 1 | 1 |
| Tim O'Connor | Walter Revere | Colonel Sloane | 1 | 1 |
| Vera Miles | Charmaine Calloway Thompson, Nancy Landon, Warden Elizabeth Gates | Millicent Barnes | 3 | 1 |
| Vincent Baggetta | Antonio Carboni, Bert Puzo, Frank Lapinski | Sailor | 3 | 1 |
| Fritz Weaver | Edwin Dupont, Judge Carter Lambert, Paris Inspector Hugues Panassié | John Sturka, The Chancellor | 3 | 2 |
| Morgan Brittany | Candice Ashcroft, Tiffany Harrow | Susan | 2 | 1 |
| Susan Oliver | Louise, Nurse Marge Horton | Teenya | 2 | 1 |
| Albert Salmi | Joe Downing | Feathersmith, Joe Caswell, Sgt. Causarano | 1 | 3 |
| Ed Nelson | Carl Turnball, Henry Post, Judge Willard Clinton | Philip Redfield | 4 | 1 |
| Antoinette Bower | Mrs. Audrey Martin | Eve Norda | 1 | 1 |
| Arte Johnson | Phil Rinker | Irv | 1 | 1 |
| Chuck Hicks | Guard | Maynard Flash, Mover | 1 | 2 |
| David Wayne | Cyrus Leffingwell | Walter Bedeker | 1 | 1 |
| Don Dubbins | Dr. Charmichael | Don Dubbins | 1 | 1 |
| Doug McClure | Gary Patterson, Sheriff Sam Rankin | Pete Grant | 2 | 1 |
| Garry Walberg | Sam Kendall | Reporter #3 | 1 | 1 |
| Gary Crosby | Ted Stully | Floyd Burney | 1 | 1 |
| Howard Morris | Uncle Ziggy | George P Hanley | 1 | 1 |
| Joe Maross | Henry Vernon | Jerry Riden | 1 | 1 |
| Pat Crowley | Trudy Howard | Jackie Benson | 1 | 1 |
| Patricia Barry | Mrs. Belle Pentworth | Ann, Leila | 1 | 2 |
| Penny Singleton | Aunt Mildred | Mrs. Flemington | 1 | 1 |
| Philip Abbott | Ed Cullen | Chris Bayles, General Stanley Eaton | 1 | 2 |
| Read Morgan | Sergeant Kevin Hogan | Lefty | 1 | 1 |
| Richard Erdman | Eggman, Jonathan | McNulty | 2 | 1 |
| Sally Kellerman | Junie Cobb | Office Worker | 1 | 1 |
| Shelley Fabares | Liza Caspar | Ellen Tillman | 2 | 1 |
| Tom Reese | Hitman | Intruder | 1 | 1 |
| Warren Kemmerling | Dr. Maurice Webster | Jud Godwin | 1 | 1 |
| John Considine | Harry Freelander, Horton Thayer, Porter Finley III | McClure | 3 | 1 |
| Michael Constantine | Ben Gibbons, Laszlo Dolby | Sheriff Charlie Koch | 2 | 1 |
| Paul Comi | Phantom | Marcusson, Psychiatrist | 1 | 2 |
| Robert Lansing | Herb Walsh, Lawrence Jarvis | Commander Douglas Stansfield | 2 | 1 |
| Rod Taylor | Inspector Rory Lanahan | Col. Clegg Forbes | 2 | 1 |
| Ann Blyth | Francesca Lodge | Pamela Morris / Constance Taylor | 1 | 1 |
| Dane Clark | FBI Agent O'Farrell | Ace Larsen | 1 | 1 |
| Earl Holliman | Sheriff J.T. Tanner | Mike Ferris | 1 | 1 |
| Edson Stroll | Dr. Peter Weber | Walter Smith | 1 | 1 |
| George Murdock | Sgt. Kaplan | Willie | 1 | 1 |
| Howard Duff | Ralph / Stephen Earl | Arthur Curtis/Gerry Raigan | 1 | 1 |
| James Coburn | Cyrus Ramsey | Major French | 1 | 1 |
| Janice Rule | Margaret Stone | Helen Foley | 1 | 1 |
| Marsha Hunt | Elvira "Ellie" Tree | Mrs. Henderson | 1 | 1 |
| Nehemiah Persoff | Constantine Stavros | Carl Lanser | 1 | 1 |
| Gerald York | Buddy #2, Man on the Phone, Second Guard | Martian Observer | 3 | 1 |
| Henry Jones | Morris Penroy | J. Hardy Hempstead | 1 | 1 |
| John McLiam | Harry Stevens | Guard | 1 | 1 |
| William Lanteau | Howard | Dolan | 1 | 1 |
| David Sheiner | Arthur Griswold, Leo Selkirk | Doc | 2 | 1 |
| Barbara Baxley | Deputy Warden Amanda Debs | Cora Wheeler | 1 | 1 |
| Lurene Tuttle | Agnes Cochran | Secretary | 1 | 1 |
| Frank Aletter | Wendell Joyner | Colonel William Connacher | 1 | 1 |
| William Phipps | Charlie | Sergeant | 1 | 1 |
| Norman Burton | Drew Narramore | Office Worker | 1 | 1 |
← Murder, She Wrote × The Twilight Zone
Cast data from TVmaze, licensed CC BY-SA 4.0.