Actors in both Desperate Housewives and Grey's Anatomy
154 actors have appeared in both Desperate Housewives and Grey's Anatomy, across 647 episodes. The most-credited is Kathryn Joosten, Karen McCluskey in Desperate Housewives and Mrs. Drake in Grey's Anatomy.
| Actor | In Desperate Housewives | In Grey's Anatomy | Eps | Eps |
|---|---|---|---|---|
| Kathryn Joosten | Karen McCluskey | Mrs. Drake | 58 | 1 |
| Kevin Rahm | Lee McDermott | Mr. Duff | 27 | 1 |
| Greg Germann | Jim Halverson | Dr. Tom Koracick | 1 | 26 |
| Gloria Garayua | 30-Year Old Celia Solis | Dr. Graciella Guzman | 1 | 24 |
| Chris Carmack | Tim | Dr. Atticus "Link" Lincoln | 1 | 20 |
| Winston Story | John | Dr. Leo Byrider | 1 | 20 |
| Debra Monk | Marcella | Louise O'Malley | 1 | 7 |
| Jeff Doucette | Father Crowley | Warren Sterman | 10 | 2 |
| Mary Pat Gleason | Elenora Butters | Marge Walker | 3 | 1 |
| Steven Culp | Rex Van de Kamp | Dr. Parker | 4 | 4 |
| Sam Page | Sam Allen | Sam Sutton | 7 | 4 |
| John O'Brien | Dr. Wheeler | Lab Tech Jeffrey | 1 | 13 |
| Gale Harold | Jackson Braddock | Shane | 15 | 2 |
| Currie Graham | Ed Ferrara | Greg | 9 | 1 |
| Alfre Woodard | Betty Applewhite | Justine Campbell | 2 | 1 |
| Brian Kerwin | Harvey Bigsby | Holden McKee | 2 | 1 |
| Mark Moses | Paul Young | Dr. Larry Maxwell | 5 | 1 |
| Sarah Paulson | Lydia Lindquist | Young Ellis Grey | 2 | 1 |
| Valerie Mahaffey | Alma Hodge | Donna Kaufman | 7 | 1 |
| Marla Sokoloff | Claire | Glenda Castillo | 3 | 2 |
Cast data from TVmaze, licensed CC BY-SA 4.0.