All 154 actors in both Desperate Housewives and Grey's Anatomy
154 actors have appeared in both Desperate Housewives and Grey's Anatomy, across 647 episodes. The most-credited is Kathryn Joosten, Karen McCluskey in Desperate Housewives and Mrs. Drake in Grey's Anatomy.
| Actor | In Desperate Housewives | In Grey's Anatomy | Eps | Eps |
|---|---|---|---|---|
| Kathryn Joosten | Karen McCluskey | Mrs. Drake | 58 | 1 |
| Kevin Rahm | Lee McDermott | Mr. Duff | 27 | 1 |
| Greg Germann | Jim Halverson | Dr. Tom Koracick | 1 | 26 |
| Gloria Garayua | 30-Year Old Celia Solis | Dr. Graciella Guzman | 1 | 24 |
| Chris Carmack | Tim | Dr. Atticus "Link" Lincoln | 1 | 20 |
| Winston Story | John | Dr. Leo Byrider | 1 | 20 |
| Debra Monk | Marcella | Louise O'Malley | 1 | 7 |
| Jeff Doucette | Father Crowley | Warren Sterman | 10 | 2 |
| Mary Pat Gleason | Elenora Butters | Marge Walker | 3 | 1 |
| Steven Culp | Rex Van de Kamp | Dr. Parker | 4 | 4 |
| Sam Page | Sam Allen | Sam Sutton | 7 | 4 |
| John O'Brien | Dr. Wheeler | Lab Tech Jeffrey | 1 | 13 |
| Gale Harold | Jackson Braddock | Shane | 15 | 2 |
| Currie Graham | Ed Ferrara | Greg | 9 | 1 |
| Alfre Woodard | Betty Applewhite | Justine Campbell | 2 | 1 |
| Brian Kerwin | Harvey Bigsby | Holden McKee | 2 | 1 |
| Mark Moses | Paul Young | Dr. Larry Maxwell | 5 | 1 |
| Sarah Paulson | Lydia Lindquist | Young Ellis Grey | 2 | 1 |
| Valerie Mahaffey | Alma Hodge | Donna Kaufman | 7 | 1 |
| Marla Sokoloff | Claire | Glenda Castillo | 3 | 2 |
| Patricia Bethune | Joyce | Nurse Ginger | 1 | 6 |
| Anne Dudek | Brandi | Elise Castor | 1 | 1 |
| Crystal Allen | Kelly | Heather | 1 | 1 |
| Ernie Hudson | Detective Ridley | Dr. Brad McDougall | 7 | 1 |
| Kurt Fuller | Detective Barton | Jerry | 5 | 1 |
| Mark Sinacori | Steel Worker | Hospital Staffer | 1 | 2 |
| Gwendoline Yeo | Xiao-Mei | Michelle Carpio | 9 | 1 |
| Bill Smitrovich | Reverend Green | Dr. Walter Carr | 2 | 2 |
| Frances Conroy | Virginia Hildebrand | Eleanor | 3 | 1 |
| Phil Abrams | Technician | Dr. Jim Nelson | 1 | 3 |
| Sharon Lawrence | Maisy Gibbons | Robbie Stevens | 3 | 1 |
| Lesley Boone | Lucy Blackburn | Judy Kemp | 2 | 3 |
| Maile Flanagan | Cashier | Tech | 1 | 4 |
| Stephen Spinella | Dr. Samuel Heller | Malar Pascowitz | 4 | 1 |
| Richard Roundtree | Mr. Shaw | Donald Burke | 5 | 1 |
| Amy Hill | Mrs. Pate | Joanne | 1 | 1 |
| Betty Murphy | Alberta Fromme | Lulu | 5 | 1 |
| Billy Mayo | Detective Lyons | Rick | 5 | 2 |
| Dale Waddington Horowitz | Nurse | OB Resident | 4 | 2 |
| Diane Farr | Barbara Orlofsky | Lila Davis | 1 | 1 |
| Ellen Crawford | Iris Beckley | Carrie Reisler | 2 | 1 |
| John Rubinstein | Principal Hobson | Keith Kalber | 5 | 1 |
| K Callan | Ilene Britt | Janis | 1 | 1 |
| Rusty Schwimmer | Toni | Patricia Phillips | 1 | 1 |
| Scott Haven | Guy #2 | Randy Begler | 1 | 1 |
| Blake Hood | Boomer | Clive Johnson | 1 | 3 |
| Joyce Guy | Nurse Kelly | Ms. Henry | 1 | 3 |
| Gregg Daniel | Dr. Sicher | Paul James | 2 | 1 |
| Jonathan Adams | Luke Rayfield | Dewayne Griffith | 1 | 2 |
| J. Omar Castro | Guard | Paramedic #2 | 1 | 4 |
| Amy Aquino | Erika Gold | Marianne Grandy | 1 | 1 |
| Caroline Aaron | Daphne Bicks | Connie | 1 | 1 |
| Jan Hoag | Beefy Middle-Aged Woman | Wheezing Patient | 1 | 1 |
| Meeghan Holaway | Elizabeth | Representative for the Doctors | 1 | 3 |
| Melinda Page Hamilton | Sister Mary Bernard | Dr. Jennifer Stanley | 3 | 1 |
| Paul Dooley | Addison Prudy | Dr. Walter Tapley | 3 | 1 |
| Peri Gilpin | Maggie Gilroy | Marcy | 1 | 1 |
| Laurie Metcalf | Carolyn Bigsby | Beatrice Carver | 4 | 1 |
| Jolie Jenkins | Deirdre Taylor | Heather Morton | 2 | 1 |
| Wayne Lopez | Clyde | Paramedic #2 | 3 | 4 |
| David Pevsner | Waiter | Examiner #2 | 2 | 2 |
| Richard Jenik | Policeman | Jimmy Shelton | 3 | 1 |
| Matt Roth | Art Shepherd | Michael Beglighter | 4 | 1 |
| Mitch Silpa | Jerry | Tim Ruggles | 3 | 2 |
| Brennan Elliott | Luke Purdue | Dave Kristler | 1 | 1 |
| Carol Mansell | Pat Ziegler | Veronica | 4 | 1 |
| Nancy Linari | Evelyn | Sophie's Daughter | 1 | 1 |
| Alison La Placa | Rita Patterson | Mrs. Nolston | 1 | 2 |
| Brent Briscoe | Jimbo Rooney | Henry Lamott | 2 | 1 |
| Mae Whitman | Sarah | Heather Douglas | 1 | 2 |
| Mark L. Taylor | Mr. Steinberg | Dave Buckley | 2 | 1 |
| Gina Hecht | Judge Mary Gallagher | Mrs. Sutton | 1 | 1 |
| Hugh Holub | Allen | Dr. Ben Warren | 1 | 1 |
| Judyann Elder | Dr. Brody | Angelica Paulson | 1 | 1 |
| Lorna Raver | Judge Sullivan | Patient In ER | 1 | 1 |
| Suzanne Cryer | Lynn Dean | Caroline Klein | 1 | 1 |
| T.J. Ramini | Yaniv | Mr. Al-Hasan | 1 | 1 |
| Todd Waring | Dr. Martin | Tobin | 1 | 1 |
| John Lacy | Detective Beckerman | Zack | 2 | 1 |
| Lisa Long | Irene Semanis | Marlene D. | 2 | 1 |
| Miriam Flynn | Dr. Berman | Ms. Bitzer | 2 | 1 |
| Amy Stewart | Darcy | Diane Early | 1 | 1 |
| Lee Garlington | Alberta Holstein | Farah Linden | 1 | 1 |
| Mark Harelik | Bob Rowland | Keith Polus | 1 | 1 |
| Maura Soden | Dr. Whitney | Librarian | 1 | 1 |
| Meagen Fay | Norma Harper | Paula | 1 | 1 |
| Michael Patrick McGill | Crime Scene Policeman | Bob Corson | 1 | 1 |
| Peter Birkenhead | Dr. Joshua Dolan | Dr. Orsen | 3 | 1 |
| Ronobir Lahiri | Nabila's Husband | Mr. Hanson | 1 | 1 |
| Sara Van Horn | Crossing Guard | Nash's Grandma | 1 | 1 |
| Soledad St. Hilaire | Helena | Lola | 3 | 1 |
| Anthony Azizi | Robert Falati | Syrian Doctor | 2 | 1 |
| James Shanklin | Detective Morgan | Lt. Moore | 2 | 1 |
| Albie Selznick | Dennis Stevens | Columbia Representative | 1 | 1 |
| Brian George | Mr. Pashmutt | Emile Flores | 1 | 1 |
| Freda Foh Shen | Dr. Chang | Missy Grant | 1 | 1 |
| Jay Cramer | Chris | Mickey Wenschler | 1 | 1 |
| Kevin Will | Ice Cream Vendor | Len Gantry | 1 | 1 |
| Carlease Burke | Nurse #2, Receptionist | Mrs. Gates | 2 | 1 |
| Craig Tsuyumine | On Site TV Reporter, Reporter | TV Reporter | 2 | 1 |
| Dougald Park | Doctor | Lawyer | 2 | 1 |
| Sandy Martin | Woman #1 | Sally | 1 | 2 |
| Adam Kulbersh | Carter | Tommy | 1 | 1 |
| Ann Ryerson | Debby | Dr. Margaret Goodwin | 1 | 1 |
| Eamon Hunt | Medical Examiner | Judge Brentner | 1 | 1 |
| Mary Passeri | Nurse | Jeannie Reed | 1 | 1 |
| Paul Hayes | Businessman | Old Man Carl | 1 | 1 |
| Mackenzie Brooke Smith | Rachel Miller | Ella | 2 | 1 |
| Wendy Benson-Landes | Colleen Henderson | Suzie | 2 | 1 |
| Annie LaRussa | Eleanor Garrett | Dorie Danzinger | 1 | 1 |
| Barry Livingston | Jimmy | Wayne Sheehan | 1 | 1 |
| Jill Holden | Betty | Naomi Cline | 1 | 1 |
| John Hemphill | Coach | Brad Nystrom | 1 | 1 |
| Mia Wesley | Leila Mitzman | Karen's Mom | 1 | 1 |
| Nealla Gordon | Sheila Bukowski | Jill Boyd | 1 | 1 |
| Patty McCormack | Teresa Pruitt | Rebecca Franklin | 1 | 1 |
| Ron Roggé | Middle-Aged Man | Fire Captain | 1 | 1 |
| Scott Allen Rinker | Priest | Toby | 1 | 1 |
| Alyssa Shafer | Little Girl #1 | Kelly Temple | 1 | 1 |
| David Grant Wright | Mr. Dinsmore | Mr. Burton | 1 | 1 |
| Susan Grace | Woman | Jane | 1 | 1 |
| Christopher Boyer | Man at Mattress Store | Tom Cline | 1 | 1 |
| Julie Wittner | Mom #1 | Mrs. Crossley | 1 | 1 |
| Ned Vaughn | Terrence Henderson | Representative for the Airline | 1 | 1 |
| Nicolette Collier | Bethany | Young Meredith | 1 | 1 |
| Sally Ann Brooks | Lea Rappaport | Marie Lamott | 1 | 1 |
| Bruce Katzman | Judge | Wayne Sheehan | 1 | 1 |
| Candace Brown | Parent | Milo | 1 | 1 |
| Jarrod Crawford | Officer #2 | Dr. Oslow | 1 | 1 |
| Kathleen Bailey | Lauren | Reproductive Counselor | 1 | 1 |
| Nelson Mashita | Postman | Dr. Bennit Epstein | 1 | 1 |
| Noah Schuffman | Brian | Randy | 1 | 1 |
| Pamela Shaddock | Nurse | Shara Freeman | 1 | 1 |
| Rob Brownstein | Rex's Lawyer | Larry | 1 | 1 |
| Wendy Schenker | Arresting Police Officer | Nervous Tenant | 2 | 1 |
| Boo Arnold | Cop #2 | Mr. James | 1 | 1 |
| Brian Chenoweth | Walter | Scared Guy | 1 | 1 |
| Catheryn Brockett | Woman | Bentley Nurse | 1 | 1 |
| Corey Mendell Parker | Doctor | Brian Wilson | 1 | 1 |
| Michael Merton | Jewelry Clerk | Dexter | 1 | 1 |
| Mike Hagerty | Gus | Al Keller | 1 | 1 |
| Vince Cefalu | Mr. Jameson | ND Patient | 1 | 1 |
| Alice Lo | Pedicurist #2 | Qing Lu | 1 | 1 |
| Andre Ware | FBI Agent #1 | Dr. Evett | 1 | 1 |
| David Goryl | Charles Babcock | Ron Campion | 1 | 1 |
| Chet Grissom | Vendor | Uncle Pat | 1 | 1 |
| Eric Payne | Investigator | Dan Pollock | 1 | 1 |
| Helen Eigenberg | Jean | Lillian Campion | 1 | 1 |
| Judy Jean Berns | Older Woman | Sue Hicks | 1 | 1 |
| Perry Smith | Gayle | Mrs. Anderson | 1 | 1 |
| Rocky McMurray | Bartender | Hunter | 1 | 1 |
| Chase Kim | Paramedic | Lawyer | 1 | 1 |
| Preston James Hillier | Fireman | Cop | 1 | 1 |
| Jeffrey Markle | Bus Driver | Greg | 1 | 1 |
← Desperate Housewives × Grey's Anatomy
Cast data from TVmaze, licensed CC BY-SA 4.0.